Both Colorado and Houston are limping into Friday’s Big 12 opener with key players sidelined, and it’s going to test their depth like never before. Colorado’s offense is missing several playmakers, while Houston’s top running back, Re’Shaun Sanford II, is out—potentially shifting the balance. With so many backups stepping up, this matchup could come down to which team adapts best under pressure. Can Colorado’s defense take advantage of Houston’s depleted backfield? Or will Houston’s healthier roster give them the edge? Let’s hear your predictions—who do you think pulls off the win? #Sports #Football #ColoradoBuffaloes