What a twist for Monday Night Football—two of the Colts’ biggest defensive stars, DeForest Buckner and Charvarius Ward, are likely out for the primetime clash against the 49ers. Both had this game circled for a shot at their former team, but injuries have robbed them—and fans—of that personal grudge match. Buckner’s absence still stings for San Francisco, who haven’t quite replaced his impact since trading him away. How do you think these absences will affect the game, and do you believe the 49ers made the right call letting Buckner go? #Sports #Football #Colts